【摘要】 小胶质细胞是脑内的主要免疫效应细胞,正常时处于“休眠状态”,无吞噬能力。脑出血后,小 胶质细胞迅速活化、增殖,发挥巨噬细胞的吞噬效应,并通过产生神经毒性分子和神经营养因子发挥 双重效应。蛋白激酶C、核因子κB和丝裂素活化蛋白激酶的活化是脑出血后小胶质细胞产生神经毒 性分子的内在机制。在一定时间窗内适当抑制小胶质细胞的活化,能减轻其细胞毒作用,改善预后。更多还原

【Abstract】 Microglia is the principal immune effector cell in brain. In normal conditions,it remains in "resting" and does not have any phagocytic function. Microglias are activated quickly and proliferate after intracerebral hemorrhage, then exert similar macrophage effector functions such as phagocytosis, and the dual effects by producing neurotoxic molecules and neurotrophic factors. The activation of protein kinase C, NF-κB and mitogen-activated protein kinase is the underlying mechanism of producing neurotoxic molecules in microglias after intracerebral hemorrhage. Appropriately suppressing the activation of microglias within a certain time window may decrease its cytotoxic effect and improve the prognosis of intracerebral hemorrhage.更多还原