【摘要】 目的:探讨在中国人群中NAD(P)H氧化酶p22phox亚基C242T多态性与缺血性脑血管病(ICVD)的相关性。方法:共收集了112例ICVD患者(TIA36例,脑梗死76例)和105例对照者,用聚合酶链反应和限制性片段长度多态性分析(PCR-RFLP)的方法确定其基因型。结果:ICVD组和对照组的TC基因型频率分别为0.152和0.057,未发现有TT基因型。ICVD组的TC基因型频率显著高于对照组(P=0.024,OR2.95,95％CI 1.12-7.81)。ICVD亚组间的分析显示,TIA与对照组之间CT基因型频率无明显差异,而脑梗死与对照组则有显著差异。结论:NAD(P)H氧化酶p22phox亚基C242T多态性可能是脑梗死的一个危险因素。更多还原

【Abstract】 Objective: To investigate the correlation between NAD(P)H oxidase p22phox C242T polymorphism and ischemic cerebrovascular diseases (ICVD) in Chinese population. Methods: One hundred and twelve patients with ICVD (36 TIAs and 76 cerebral infarctions) and 105 control subjects were recruited. C242T polymorphism of p22phox was analyzed by polymer-ase chain reaction and restriction fragment length polymorphism (PCR-RFLP) for determining its genotype. Results: The TC genotype frequencies in the ICVD group and control group were 0. 152 and 0. 057, respectively, and no TT genotype was found. The TC genotype frequency of the ICVD group was significant higher than that of the control group (P =0. 024, OR 2. 95, 95% CI 1. 12-7. 81). Analysis of ICVD between the subgroups showed that there was no significant difference between the TIA and the control group in CT genotype frequencies, but there was significantly difference between the cerebral infarction group and the control group. Conclusion: The NAD(P)H oxidase p22phox C242T polymorphism may be a risk factor for cerebral infarction.更多还原