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鱼腥草注射液对小鼠学习记忆能力的影响
Effect of Herba Houttuyniae injection on the ability of le arning and memory of mice
【摘要】 目的 :研究鱼腥草注射液对小鼠学习记忆能力的影响并分析其机制。方法 :将经过预筛选的小鼠随机分组 ,通过迷宫实验以及测定脑组织中丙二醛 (MDA)、超氧化物歧化酶 (SOD)、乙酰胆碱酯酶 (AChE)、一氧化氮合酶 (NOS)的含量或活性 ,判定鱼腥草注射液对小鼠学习记忆能力的作用。结果 :鱼腥草注射液可以提高小鼠Y迷宫测试的正确次数 ,提高脑组织中SOD和NOS的活性 ,降低脑组织中MDA的含量。结论 :鱼腥草注射液对小鼠学习记忆能力具有促进作用 ,并具有抗氧化作用。
【Abstract】 Objective To study the effect of Herba Houttuynia e injection on the ability of learning and memory of mice, then analyse its mechan ism. Method Pre-selected mice were randomly divided into five groups of different content of Herba Houttuyniae, applying Y-maze and colorimet er were used and the content of MDA, the enzyme activity of SOD of mice brai n, AChE and NOS were measured. Result Herb a Houttuyniae injection increased the correct actions of mice in Y-maze and increased the enzyme activity of SOD and NOS , but the content of MDA decreased. Conclusion Herba Houttuyniae injection can enhance the ability of learning and memory of mice, and has the effect of antioxidation.
【Key words】 Herba Houttuyniae injection; learning and memory; mal ondialdehycle; superoxide dismutase; acetylcholine esterase; nitric oxide synthase; mice;
- 【文献出处】 东南大学学报(医学版) ,Journal of Southeast University , 编辑部邮箱 ,2004年06期
- 【分类号】R285
- 【被引频次】7
- 【下载频次】152