【摘要】 目的　探讨异基因外周血造血干细胞移植 ( Allo-PBSCT)后患者 ABO、Rh血型的转变在血液病移植治疗中的意义。方法　选择 2例非血源关系的供、受者作为研究对象 ,采用基因分型与血清学方法检测移植前后 ABO、Rh血型的表达 ,追踪移植后患者血型基因型与抗原的转变。结果　 2例患者分别在移植后第 7天与第 1 0天检测到供者的 A、Rh( c)基因 ,第 7天与第 1 5天不同程度地表达供者的 ABO、Rh血型抗原。结论　观察 ABO与 Rh血型的转变可作为植入证明的检测方法之一 ,且直观、迅速。更多还原

【Abstract】 Objective To explore the significance of ABO,Rh blood group conversion after allogeneic peripheral hematopoietic stem cell transplantation(Allo-PBSCT) in the treatment of hematological diseases.Methods The two patients were transplanted with ABO,Rh-incompatible peripheral hematopoietic stem cell. The ABO,Rh genotype and phenotype were detected before and after Allo-PBSCT.Results The mixed field was detected in peripheral blood from +7 d and +15 d, respectively.The A,Rh(c) genotypes of donors were observed on 2 patients from +7 d and +10 d.Conclusion Observing the ABO,Rh blood group genotype and phenotype conversion could be used to evaluate the graft quality after allogeneic hematopoietic stem cell transplantation. And it is a direct and rapid method.更多还原