【摘要】 目的　了解心肌型脂肪酸结合蛋白在急性心肌梗死 (AMI)后血清浓度变化特征 ,探讨其对AMI的潜在价值。方法　采用酶联免疫吸附实验一步夹心法对 12 6例健康体检者和 5 3例AMI患者进行血清心肌型脂肪酸结合蛋白(H FABP)检测 ,其中AMI患者分为再灌注组和非再灌注组 ,同时测定肌红蛋白、心肌型肌酸激酶同工酶、肌钙蛋白I,以各自的诊断参考值为基值作标准化比值时间曲线进行动态分析。结果　AMI后 2hH FABP和肌红蛋白血清浓度明显升高 ,峰值时间及恢复时间较肌酸激酶同工酶和肌钙蛋白I前移 ,脂肪酸结合蛋白、肌钙蛋白I峰值标准化比值显著高于肌红蛋白、肌酸激酶同工酶 ,再灌注组的H FABP较非再灌注组曲线前移和峰值增高更为显著。结论　H FABP将是一种可为临床提供多种有用信息 ,有重要临床价值的AMI心肌标志物更多还原

【Abstract】 Objective To know the characteristics of change in heart-type fatty acid-binding protein(H-FABP) in AMI and decide the potential value of H-FABP for AMI.Methods Serum H-FABP of 126 healthy individuals and 53 AMI patients was measured by ELISA.Myoglobin(MYO),troponin I(cTnI),creatine kinase-MB(CK-MB) were estimated at the same time.The dynamic changes of plasma concentrations of these markers after AMI and the normalized ratios based on the respective threshold values were analyzed.Results The plasma concentrations of H-FABP and MYO increased obviously at 2 hours after onset of AMI symptom and their peaking and recovering time seemed earlier than those of CK-MB and cTnI.The normalized ratios of H-FABP and cTnI were remarkably higher compared with MYO and CK-MB.The dynamic curve of H-FABP in the reperfused group shifted ahead and the peak was higher in comparison with the non-reperfused group.Conclusion H-FABP may be an important myocardial indicator that can provide multiple useful information for AMI.更多还原