【摘要】 目的:比较美沙酮与硫酸吗啡控释片治疗中、重度癌痛的止痛效果和不良反应。方法:60例中、重度癌痛患者(应用第二阶梯止痛药不能缓解者),随机分为两组,治疗药物分别为美沙酮组和美施康定组,在用药后15天评价疼痛缓解率及不良反应。结果:疼痛缓解率美沙酮组为83.3％(25/30),美施康定组86.7％(26/30),差异无显著性(P>0.05)。美施康定组便秘、恶心及呕吐发生率显著高于美沙酮组,差异有显著性(P<0.05)。结论:美沙酮由于对中、重度癌痛的止痛效果好,副作用低,为治疗中、重度癌痛较好的药物。更多还原

【Abstract】 Objectives: To compare the analgesic effect and side effects between methadone hydrochloride tablets and morphine sulfate controlled-release tablets (MST). Methods: 60 patients with moderate or severe cancer pain were randomly divided into two groups. One groups was methadone hydrochloride tablets group (experiment group),another was MST group(control group). To evaluate the effective rates and side effects after using of the two medicines 15 days later. Results: The relieving rate of cancer pain is 83.3%(25/30)(experiment group) and 86.7%(26/30) (control group). There was no statistically significant difference between the two groups(P>0.05). The occurring rate of constipation,nausea and vomit of control group is higher than that of experiment group. There were statistically significant differences between the two groups (P<0.05). Conclusions: Methadone hydrochloride tablets has good effects to relieve moderate or severe cancer pain and it has low side effects. A methadone hydrochloride tablet is a better medicine to treat moderate or severe cancer pain.更多还原