【摘要】 目的 了解慢性乙型肝炎患者血清HBVDNA含量与肝组织损伤及纤维化程度的相关性。方法 对64例HBsAg阳性的慢性乙型肝炎进行肝穿刺病理检查 ,HBVDNA定量采用荧光定量系统 ,HBVM采用ELISA法。结果 慢性中、重度肝炎较慢性轻度肝炎血清HBVDNA含量有显著性差异 ,而慢性中、重度肝炎之间差异不显著 ,同样肝组织炎症分级G1、G2、G3随着炎症分级的增高 ,其血清HBVDNA含量也逐渐增高 ,而在G4级较G3级反而有所下降 ;血清HBVDNA含量与肝组织纤维化分期无明显关系 ;血清HBVDNA含量随着血清胆红素水平的升高有下降的趋势。结论 血清HBVDNA水平与肝组织损伤有一定的关系 ,与肝纤维化程度无明显关系更多还原

【Abstract】 Objective To explore the correlation between hepatic damage or hepatic fibrosis and quantity of serum HBV DNA of patients with chronic hepatitis B. Methods Sixty-four patients suffering from chronic hepatitis B with positive HBsAg were performed liver puncture for pathological examination. The quantity of serum HBV DNA was detected by fluorescence ration PCR analysis system. Hepatitis B virus markers were detected by ELISA. Results There was significant difference in quantity of serum HBV DNA between moderate or severe chronic hepatitis and mild chronic hepatitis, while no significant difference was found between moderate and severe chronic hepatitis. With the development of hepatic damage degree of G1, G2, G3, the serum HBV DNA concentration elevated accordingly. But serum HBV DNA concentration in hepatic damage degree G4 was lower than that in hepatic damage degree G3. There was no significant correlation between serum HBV DNA content and the hepatic fibrosis degree. With the elevation of the serum bilirubin level, the serum HBV DNA content tended to decline.Conclusions There is certain correlation between serum HBV DNA content and hepatic damage, but no correlation between serum HBV DNA content and hepatic fibrosis degree.更多还原