【摘要】 丝裂霉素C(MMC)是一种广谱抗肿瘤药物,它在体内活化后可以与DNA以共价结合或交联反应等模式相互作用,从而抑制肿瘤细胞DNA的合成。文中首次采用光谱学方法,结合紫外 可见光谱、圆二色光谱手段,提出了MMC的酸活化机理。证明它是一个质子化水解过程,同时推导了酸活化第一步基元反应的反应级数和反应速率常数的计算公式,并计算得该基元反应的速率常数k为3.083×10-4s-1。更多还原

【Abstract】 Mitomycin C （MMC） is a broad-spectrum antitumor drug, which inhibits the synthesis of DNA of the tumour cell, due to the covalent or interlinking interaction with DNA after its activation in human body. The mechanism of the acid activation of MMC is studied for the first time by spectrometry, including the UV-VIS spectrophotometry and the circular dichroism spectrometry. It is proved that it is a process of protonated hydrolysis. The reaction order of first step of the basic reaction of acid activation is deduced and the constant of reaction rate k is calculated to have a value of 3.083×10^-4s^-1.更多还原