【摘要】 [目的 ]采用中文版计算机化神经行为评价系统 (NES -C)中 6个测试项目 (视简单反应时、视复杂反应时、符号译码、长度判断、连续识别记忆和系列加减 )来评价急性低氧环境对人神经行为功能的影响。 [方法 ]采用自身对照的方式 ,64名受试者先在正常情况下进行测试作为本底 ,然后分成 4组 ,分别在模拟 2 5 0 0m、3 0 0 0m、3 5 0 0m与 40 0 0m高空、低氧环境 (呼吸面罩吸入空气中氧分压分别为 15 .1% ,14 .1% ,13 .1%和 12 .2 % )下适应 5min后 ,进行神经行为功能测试。 [结果 ] 4组受试者的视简单反应时均明显降低 (P <0 .0 5 ) ,显示受试者的反应能力受到影响 ;长度判断正确数呈下降趋势 ,视复杂反应时延迟 ,但差异无显著性 ;符号译码、连续识别记忆和系列加减 ,与本底均无明显差异。逐步回归分析显示随着血氧饱和度降低 ,符号译码总数、长度判断正确数下降 ,视简单反应时与视复杂反应时的最小值增大。[结论 ]急性低氧环境可明显影响受试者视简单反应能力 ;血氧饱和度降低对符号译码、长度判断、视简单反应时与视复杂反应时等综合感知和反应能力均有影响更多还原

【Abstract】 Objective To assess the neurobehavioral effects of hypoxia under a simulating high altitude work environment. [Methods] A self-control study was conducted. 6 subtests(simple visual reaction time,SVRT; choice visual reaction time,CVRT; symbol digit substitution,SDS; continuous recognition memory,CRM; length discrimination,LD; and series addition and subtraction,SAS) of Neurobehavioral Evaluation System in Chinese version(NES-C) are applied to the evaluation of neurobehavioral effects among 64 volunteers recruited at the simulated high altitude environment. The subjects were classified into 4 subgroups according to the simulated high altitude at different height of 2 500 m,3 000 m,3 500 m and 4 000 m. Each subject is asked to perform the 6 sub-tests under normal and hypoxia work conditions. [Results] The SVRT was obviously delayed,suggesting that the ability of reaction is descended under a hypoxic environment; the performances of LD and CVRT were poorer although they did not show significantly difference from the baselines. By stepwise equation analyses,the results illustrated that the lower the arterial oxyhemoglobin saturation (SaO 2) determined,the poorer the neurobehavioral performance conducted,this was reflected in most of the results of the subtests,such as SDS,LD,SVRT and CVRT. [Conclusion] The results suggeste that acute hypoxic work environment deteriorates certain type of human neurobehavioral functions. The visual recognition and reaction abilities are significantly affected.更多还原