【摘要】 目的 :本文观察了Qi盐对大鼠实验性高血脂、血黏度及人RBC变形能力的作用。方法 :建立大鼠高血脂模型 ,将Qi盐灌胃给予上述大鼠 ,剂量分别为 0 0 5 ,0 1,0 3,1g·kg-1,连续 2 0d后 ,检查大鼠血脂的变化。体外将人RBC与不同浓度Qi盐混合 ,使RBC溶液中含 0 1,0 2 ,0 4 ,0 8,1 6g·L-1Qi盐 ,37℃孵育 1h后 ,用微孔滤膜法测RBC变形能力 ;正常大鼠连续灌胃Qi盐 2 0d ,剂量分别为 0 1,0 3,1g·kg-1,采血测血黏度。结果 :Qi盐降低大鼠血胆固醇和LDL胆固醇 ,而 1g·kg-1Qi盐还增加大鼠血HDL 胆固醇 ;Qi盐能增加人RBC变形能力 ,0 .8g·L-1浓度时作用最强 ,浓度增高或降低 ,对RBC变形能力的影响减弱 ;0 3g·kg-1或 1g·kg-1的Qi盐可提高全血血黏度 ,但提高幅度不及普通盐。结论 :Qi盐能增加RBC变形能力 ,且有一定的降低血脂趋势更多还原

【Abstract】 AIM: To test the effect of Qi salt on rat experimental hyperlipemia, red blood cell deformability and blood viscosity. METHOD:(1) The Qi salt was given to the rats with hyperlipemia that caused by fat-rich diet for 20 d. The serum HDL-C, LDL-C, total cholesterol and triglyceride were determined. (2) The human red blood cell was incubated with different concentration of Qi salt at 37℃ for 1h. Then the red blood cell deformation was measured by method of micro-pore infiltration. (3) The normal rats were treated with Qi salt for 20 d. The blood was drained from common carotid artery and the viscosity was tested. RESULTS: (1) The serum total cholesterol and LDL-C were lowered by Qi salt and the HDL-C was increased by 1g·kg -1 Qi salt. (2) The Qi salt had the ability to enhance the deformation of human red blood cell, the most effective concentration was 0.8 g·L -1. Increasing or decreasing the concentration lead to drop of the effect. (3) High dose of Qi salt may increase the blood viscosity but it was less strong than normal salt. CONCLUSION: Qi salt could increase the red blood cell deformation and may lower the serum lipid.更多还原