【摘要】 目的 :观察三氧化二砷 (As2 O3 )联合化疗治疗难治性及复发性恶性血液病的疗效和不良反应。方法 :As2 O3 联合蒽环类药物、阿糖胞苷及足叶乙甙治疗难治性及复发性恶性血液肿瘤患者 33例 ,治疗方法是用As2 O3 (0 .1%溶液 ) 10ml加入 5 %葡萄糖溶液 5 0 0ml中静脉滴注 3～ 5h ,每天 1次 ,共治疗 30天 ;对复发性早幼粒细胞白血病、加速期慢性粒细胞白血病及骨髓增生异常综合征患者用As2 O3 联合柔红霉素 4 5mg·m-2 ·d-1× 3天加阿糖胞苷 10 0mg/m2 q12h× 7天治疗 ;对进展期多发性骨髓瘤和ⅢB～Ⅳ期非霍奇金淋巴瘤患者用As2 O3 联合米托蒽醌 8～ 10mg·m-2 ·d-1× 3天加足叶乙甙 6 0mg·m-2 ·d-1× 5天加Pred 1mg/kg× 7天加长春新碱 2mg× 1天治疗。结果 :33例患者中 ,19例获得完全缓解 (CR) ,2 7例有效 ,CR率为 5 7.8% ,有效率为 81.8%。结论 :As2 O3 联合化疗治疗难治性及复发性恶性血液病疗效好 ,不良反应少更多还原

【Abstract】 Objective:To observe the efficacy and side effect of the arsenic trioxide combining standard does chemotherapy in treatment of drug resistance and relapse hematological malignancies.Method:thirty three patients were treated with arsenic trioxide combining standard does chemotherapy. the treatment protocol was as following:10 mg As 2O 3 (0.1%solution)in 500 ml 5%glucose solution for intravenous drip over 3 to 5 hours once a day.The relapse acute promyelocytic leukemia.(APL) ,accelerated phase chronic myeloid leukemia(CML AP) and myelodysplastic syndromes refractory anemia with excess blasts in transformation(MDS RAEBT) patients are treated with daunorubicin 45 mg·m -2 ·d -1 ×3 d+cytarabine 100 mg/m 2 q12h ×7 d. Evolutional Multiple Myeloma and ⅢB ⅣNon Hodgkin’s lymphomas patients are treated with mitoxantrone(8～10)mg·m -2 ·d -1 ×3 d+ Etoposide 60 mg·m -2 ·d -1×5 d+ Pred 1 mg/kg×7 d+Vincristine 2 mg×1 d.Result:nineteen patients achieved complete remission(CR),the CR rate was 57.8 %,treatment effective rate was 81.8 %.Conclusion:the As 2O 3 combined with standard does chemotherapy for the treatment of drug resistance and relapse hematological malignancies showed a higher CR without intolerable side effects.更多还原