【摘要】 目的 :探讨不同类型冠心病患者可溶性E 选择素 (SES)、C 反应蛋白 (CRP)的变化及其临床意义。方法 :将 81例患者按临床诊断分为 4组 :急性心肌梗死 (AMI)组 17例 ,不稳定型心绞痛 (UAP)组 2 4例 ,稳定型心绞痛 (SAP)组 2 0例和对照组 2 0例。分别检测各组患者SES及CRP水平 ,对冠心病患者的冠状动脉损害行Gensini评分 ,并比较各组间的差异。结果 :①AMI组、UAP组及SAP组的SES、CRP水平高于对照组 ;②AMI组、UA组SES及CRP水平与SAP组相比 ,其值明显增加 ;AMI组和UAP组SES水平相近 ,AMI组CRP高于UA组 ;③冠状动脉多支病变组SES、CRP的含量高于单支病变组。随着冠状动脉病变Gensini评分的增加 ,SES、CRP升高越明显。结论 :SES、CRP是冠心病病情监测和评价粥样斑块不稳定性的非侵入性指标 ;它们的升高程度与冠状动脉病变程度有良好的相关性更多还原

【Abstract】 Objective: To investigate the clinical significance of soluble E-selectin(SES) level and C-reactive protein(CRP) in different subtype of coronary heart disease(CHD). Methods: The study groups included 17 cases of acute myocardial infarction (AMI) group , 24 unstable angina pectoris (UAP) group, 20 stable angina pectoris (SAP )group ; the control group included 20 healthy. Serum levels of SES were measured by Enzyme-Linked Immunosorbent Assay. The severity of coronary lesion was graded with Gensini Score.Results: ①The levels of SES and CRP were elevated in AMI group, UAP group and SAP group compared with control group. ②Compared with SAP group, the levels of SES and CRP were elevated in AMI group and UAP group; compared AMI group with UAP group, there was no significant difference in the levels of SES, but the level of CRP was elevated in AMI group. SES and CRP concentration positively correlated with Gensini Score. Conclusion: SES and CRP can be used as non-invasive markers of coronary plaque destabilization and the severity of CHD.更多还原