节点文献

Ⅲ期乳腺癌术前新辅助化疗的临床观察

Preoperative adjuvant chemotherapy in patients with stageⅢ breast cancer

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 周勇冯刚张勇王建祥

【Author】 ZHOU Yong,FONG Gang,ZHANG Yong,et al.(Department of General Surgery,Puai Hospital,Wuhan 430033,China)

【机构】 武汉市普爱医院普外科武汉市普爱医院普外科 430033430033

【摘要】 目的 研究Ⅲ期乳腺癌术前新辅助化疗的临床效果。方法  1999年~ 2 0 0 1年 6月住院手术治疗的Ш期乳腺癌患者 62例 ,术前行辅助化疗 ,回顾分析 1997~ 1998年间收治的 3 7例Ш期乳腺癌未作辅助化疗而直接手术作为对照组。从手术切除后病理切片观察细胞变化及术后局部复发 ,远处转移等方面进行比较。结果 手术后病理切片观察癌细胞坏死情况 ,新辅助化疗组有效率为 67.7% ,而对照组仅 6例癌细胞有轻度局灶坏死。术后三年局部复发或远处转移新辅助化疗组为 11.4% ,对照组 2 4.3 %。结论 手术前辅助化疗能大量杀伤肿瘤细胞 ,缩小肿瘤便于手术 ,减少远处播散机会

【Abstract】 Objective To study the efficacy of preoperative adjuvant chemotherapy in stage Ⅲ breast cancer.Methods Between june 1999 and june 2001,a total of 62 hospitalized patients with stage Ⅲ breast cancer who underwent preoperative adjuvant chemotherapy in this study.37 patients with stage Ⅲ breast cancer on whom surgery were performed did not receive any Neoadjuvant chemotherapy between 1997 and 1998,and served as controls.The histologic inveatigations and the rate of the metastases or local recurrence were compared.Results Tumor cell necrosis was investigated by postoperative pathological study and revealed that the response rate in preoperative adjuvant chemotherapy group was67.7%,only 6 cases in control group showed mild necrosis.the 3-year transcatheter and local recurrence rate of the trereatment group was 11.4%,that of the other group was 23.7%.Conclusion Neoadjuvant chemotherapy in patients with stage Ⅲ breast cancer may destroy large numbers of tumor cells vigrously,The preliminary results are satisfy.

  • 【文献出处】 临床外科杂志 ,Journal of Clinical Surgery , 编辑部邮箱 ,2004年12期
  • 【分类号】R737.9
  • 【被引频次】1
  • 【下载频次】57
节点文献中: 

本文链接的文献网络图示:

本文的引文网络