【摘要】 目的 评价国产奎硫平对精神分裂症患者的疗效和副作用。方法 将60例首次住院的精神分裂症女性患者随机分为两组,每组30例,分别用奎硫平和利培酮治疗6w,采用PANSS评定疗效,TESS评定副反应。结果奎硫平组显著进步20例,进步6例,无效4例;利培酮组分别为18例,9例和3例,两组比较差异无显著性(P>0.05)。两组疗前与疗后各周PAN-SS总分比较均有显著性差异(P<0.01),但两组间比较差异无显著性(P均>0.05)。两药均在第2w开始起效,两组疗效无显著性差异。两组不良反应均为轻至中度,发生率及严重程度无显著性差异。结论 奎硫平对精神分裂症有肯定疗效,且安全性高。更多还原

【Abstract】 Objective To assess efficacy and side effects of domestic quetiapine in the treatment of schizophrenia. Methods 60 first-admitted famale schizophrenics were randomly divided into two groups(each n= 30) receiving quetiapine and risperidone respectively for 6 weeks. The efficacies and side effects were assessed with PANSS and TESS respectively. Results Both drugs took effects in the 2nd week and the efficacies of the 2 groups were equivalent. The side effects of both 2 groups were mild to moderate degree and had no significant difference in incidence and severity. Conclusion Ouetiapine is an effective and safe drug in the treatment of schizophrenia.更多还原