【摘要】 目的 探讨精神分裂症长期服药患者的疗效、安全性、社会功能、复发风险及换用利培酮的可行性。方法 对87例资料完整患者入组前与换药后2、4、6、8w末,用自制表格对患者的生活质量及依从性进行评定。结果 精神分裂症长期服药患者换用利培酮后可以进一步改善精神症状与认知功能,提高生活质量和依从性,有效降低复发风险,且安全性好。结论利培酮治疗精神分裂症较传统抗精神病药物疗效好(症状、不良反应和生活质量)。更多还原

【Abstract】 Objective To explore the curative effect, safety, social function and relapse risk and the practicability of risperidone replacement for schizophrenics who took medicine long. Methods Life quality and compliance were assessed by self-made sheet in 87 patients with whole data before enrolment and at the ends of 2nd,4th,6th and 8th week during replacement. Results Risperidone replacement could further improve symptoms, cognitive function, life quality and compliance, and effectively reduce relapse risk and had better safety. Conclusion Curative effect of risperidone is better than that of traditional antipsychotics.更多还原