【摘要】 目的 :探讨抗周围神经膜表面糖脂抗体在自身免疫介导的多发性周围神经病中的临床意义。方法 :ELISA法测定格林 巴利综合征和慢性炎性脱髓鞘性周围神经病患者血清中抗硫脂抗体和 7种节苷脂抗体 (GM1、GM2、GA1、GD1a、GD1b、GT1b和GQ1b)的阳性率。结果 :GBS和CIDP组患者抗硫脂抗体、抗GM1、GA1和GD1b抗体的阳性率显著高于非自身免疫性周围神经病组 (P <0 0 5 ) ;此两组患者间的抗体阳性率比较则无显著差异 ;GBS组内有眼 /咽肌麻痹的患者 (17例 )与无眼肌和 (或 )咽喉肌麻痹患者 (2 5例 )的节苷脂抗体阳性率也无显著差异。结论 :血清抗硫脂抗体和抗GM1抗体增高对自身免疫介导的多发性周围神经病患者有一定临床意义。更多还原

【Abstract】 Aim:Anti-sulfatide and anti-gangliosides antibodies were detected to define the association between these antibodies and the different spectrum of autoimmune mediated polyneuropathies.Methods:The antibodies of the patients with Guillain-Barre syndrome(GBS),chronic inflammatory demyelinating polyneuropathies (CIDP) and the other polyneuropathies (OPN) were detected by enzyme-linked immmunosorbent assay (ELISA).The positive sera were those OD value higher than the mean +3SD of the normal controls for each glycolipids.Results:The anti-sulfatide,anti-GM1,anti-GA1,and anti-GD1b andtibodies of the GBS and CIDP were all significantly higher than those of the OPN.No predominance of these antibodies was seen.Conclusion:The wide distribution of these glycolipids in the peripheral nerve and the low titer of these antibodies in the normal subject suggested an epiphenominen of these increased antibodies in the patients with autoimmune mediated polyneuropathy.更多还原