【摘要】 目的 :评价加巴喷丁在癫治疗中的有效性和安全性。方法 :采用多中心随机双盲研究 ,用加巴喷丁添加治疗各型癫 ,观察有效性和安全性。结果 :随机入组病例 2 3 6例 ,进入疗效分析的为 2 0 5例。服用加巴喷丁的病人每 4周随访时的癫发作次数均减少 ,且在用药后第 12周与对照组的差别有统计意义。治疗有效率在用药后第 12、2 0周与对照组的差别有统计意义 ,且在全身强直阵挛发作者和部分性发作继发全身性发作者中更明显。安全性两组无差异。结论 :加巴喷丁在添加治疗癫的疗效显示较安慰剂组在减少癫发作次数和治疗有效率等方面均有较好的疗效 ,同时也是一个安全性较好的药物。更多还原

【Abstract】 Aim:The purposes of this study were to assess the safety and efficacy of the gabapentin in adding on treatment of epilepsy patients.Methods:The placebo-controlled,double-blind studies were performed in our country by five hospitals of different provinces(cities). The times of seizure,MMSE and ADL were observed in every 4 weeks to decided the efficacy,and the side effect was also observed to assess the safety.Results:205 patients were studied.106 patients take gabapentin 1200 mg/d,99 patients with placebo.The times of seizure were reducing in patients with gabapentin than with placebo in every 4 weeks,and there were statistic changes in 12 weeks,20 weeks.There was little difference of side effects in the two groups.Conclusion:Gabapentin at a dosage of 1200 mg/d was safety and efficacy in epilepsy.更多还原