【摘要】 目的　研究大脑胶质瘤病的临床、影像学和病理学的特征。方法　对 2例大脑胶质瘤病患者行脑MRI平扫、增强扫描及病灶的病理学检查 ,并追踪观察其临床经过。结果　 2例患者临床主要表现有头痛、头晕、恶心呕吐、复视、偏瘫、偏身感觉障碍及共济失调等症状。脑MRI示双侧大脑颞叶、顶叶、胼胝体、丘脑、尾状核、壳核片状长T2 信号 ,边界不清 ,无占位效应。其中 1例脑干、小脑片状长T2 信号 ,注射Gd DTPA后 1例无强化 ,另 1例可见不规则强化。病理学所见 :镜下病变区可见多数星形胶质瘤细胞呈弥漫性浸润性生长 ,细胞核有圆形、椭圆形 ,核染色较深 ,少见核分裂。 2例患者于发病后 4～ 6个月内死亡。结论　脑MRI和活组织病理学检查是诊断本病的必要手段。本病预后不良。更多还原

【Abstract】 Objective To study the clinical,image and pathological features of cerebral gliomatosis.Methods 2 cases with cerebral gliomatosis underwent routine MRI scan, contrast enhance MRI scan and pathologic examination of the lesions. Their clinical manifestations were observed during the past 2 years.Results Main clinic features of the 2 patients were headache, dizziness, nausea, vomit, diplopia, hemiplegia, hemianesthesia and ataxia. Cranial MRI scan showed long T 2 signals in the bitemporal lobes, biparietal lobes, corpus collosum, thalamus, caudate nucleus and putamen. Brain stem and cerebellum were also involved in 1 patient. The borders of the lesions were unclear and no mass-effect phenomenons were found. Contrast enhancement occurred only in 1 patient after Gd-DTPA injection. The biopsies in the 2 patients showed diffuse infiltrative growth of most astroglioma cells. The shape of nucleus was round or ellipse and the staining of nucleus was comparatively deep. Cleavage of nucleus was seldom. The 2 patients died in 4 to 6 months after the onset of the disease.Conclusions MRI scan and pathologic examination are essential diagnostic methods for cerebral gliomatosis. The prognosis of cerebral gliomatosis is poor.更多还原