【摘要】 目的 :探讨供受者HLA致敏原性错配 (IM )对肾移植受者急性排斥反应发生率的影响。方法 :回顾性分析 196例首次肾移植受者IM对肾移植术后肾功能的恢复时间及 1年内排斥反应发生率情况。结果 :IM对肾移植术后肾功能恢复时间无明显影响 ;IM患者 1年内急性排斥率明显增加 ;各类位点IM对肾移植术后急性排斥反应的影响进行比较 ,A位点影响不大 ,B位点与急性排斥反应有关 ,DR位点IM可致急性排斥反应明显增加。结论 :在临床采用氨基酸残基配型标准判断组织配型的同时 ,IM不容忽视 ,HLA B位点IM与肾移植术后急性排斥反应相关 ,HLA DR位点IM明显影响肾移植术后排斥反应发生率更多还原

【Abstract】 Objective:Investigate influence of HLA immunogenic missmatching (IM) on the rate of acute rejection of the renal recipients.Method:The renal functional recovery time and the rate of aucte rejection of 196 cases with cadaveric renal transplantation were analysed.Result:Renal function of all recipients got right within seven days,rejection did not occur within 7 days after renal transplantation. When the numbers of MM loci were less 3, rejection incidence was lower, when the numbers of MM >3, the more the numbers of IM, the higher was rejection incidence. HLA A loci IM had no influence to acute rejection, IM of HLA B and DR loci submit positive correlation with acute rejection. In the observation of influence of HLA sensitization mismatching on recipient/graft survival rate, it was found that recipient/graft survival rate were related with acute rejection clearly.Conclusion:MM and IM of HLA loci did not affect the graft’s functional recovery time;When MM>3, the numbers of MM and IM were related to acute rejection. In this study, MM and IM of HLA A loci had no influence to acute rejection, IM of HLA B and DR loci submit positive correlation with acute rejection.更多还原