【摘要】 目的　调查正常孕妇血清脂蛋白 (a) [Lp(a) ]的含量以及在妊娠过程中Lp(a)的变化特征。 方法　采用ELISA法检测2 88例正常孕妇血清Lp(a)含量 ,以 92例非孕年轻女性作对照。同时检测其他血脂指标。 结果　妊娠组和非妊娠组的Lp(a)含量有显著差异 ,分别为 (96 .0± 10 4 .7)mg/L和 (73.8± 83.7)mg/L(P <0 .0 1)。不同妊娠期比较发现中妊组 (2 1～ 2 8周 )和晚妊组 (2 9～ 4 0周 )Lp(a)水平明显高于早妊组 (12～ 2 0周 ) (P <0 .0 5 ) ,约为早妊组的 2倍 ,中妊组和晚妊组Lp(a)水平无差异。其他血脂及载脂蛋白水平随着孕周的增加也显著升高。结论　妊娠期Lp(a)含量的变化可能与孕妇在正常妊娠过程中雌激素水平升高有关 ,是孕妇在妊娠过程中的一种生理需要更多还原

【Abstract】 Objective To investigate the changes of the concentrations of lipoprotein (a) in normal pregnant women and its involved clinical significance.Methods Serum concentrations of lipoprotein (a) were measured in 288 healthy pregnant women by ELISA.The levels of other serum lipid and lipoproteins were simultaneously determined on a model 7600 automatic analyzer (Hitachi).The controls were 92 nulliparous healthy young women.Results Serum lipoprotein (a) concentration in normal pregnant women increased significantly as compared with nulliparous controls (96.0±104.7 mg/L vs 73.79±83.7 mg/L,P<0.01).Other serum lipids and lipoproteins levels in normal pregnant women also increased significantly as compared with the controls.The levels of lipoprotein (a) in the both groups with 21 to 28 weeks and 29 to 40 weeks of gestation were markedly elevated as compared with those in group with 12 to 20 weeks of gestation(P<0.05).In addition,all serum lipid and lipoproteins measured increased with the progression of gestation.Conclusion The elevation of lipoprotein (a) level may be a result of increased estrogen level and be necessary for pregnant physiological requirement during pregnancy.更多还原