【摘要】 目的　采用单层CT动态成像测定肝脏血流量 ,探讨CT灌注成像测定肝血流量的技术原理。资料与方法　 15例经临床及实验室、B超检查诊断为肝硬化患者 ,其中ChildB级者 10例 ,ChildC级者 5例。对照组为 13例无肝脏疾病者。所有患者均选取同时含有肝脏、脾脏、主动脉和门静脉的层面进行单层CT动态增强扫描 ,绘制感兴趣区时间 密度曲线计算肝脏血流量各参数。结果　正常组肝动脉灌注量 (HAP)为 0 .2 82 3± 0 .0 96 9ml·min-1·ml-1,门静脉灌注量 (PVP)为 (1.1788± 0 .4 0 0 4 )ml·min-1·ml-1,总肝血流量 (THBF)为 (1.4 5 6 3± 0 .4 4 39)ml·min-1·ml-1,肝动脉灌注指数 (HPI)为 (19.73± 5 .81) %。肝硬化时PVP为 (0 .6 12 1± 0 .2 5 4 4 )ml·min-1·ml-1,较正常组降低 ;THBF也减低 ,为 (0 .84 2 6± 0 .32 4 2 )ml·min-1·ml-1。肝硬化患者的HPI较正常组略有升高 ,为 (2 7.16±12 .75 ) % ,但无统计学差异 (P =0 .0 6 5 )。结论　肝脏CT灌注成像可定量测定肝脏血流量参数更多还原

【Abstract】 Objective To estimate hepatic blood flow with CT single-slice dynamic imaging, to introduce its technical principles.Materials and Methods Fifteen cases with clinically- or laboratory-proved cirrhosis were collected, of which 10 were classified into Child B and 5 into Child C. The control group included 13 individuals without hepatic diseases. Single-slice dynamic enhanced CT scanning at a level containing the liver, spleen, aorta and portal vein was carried out in all cases. Time-density curve of the region of interest (ROI) was obtained and the hepatic blood flow, including arterial, portal and total perfusion of the liver, was calculated. The hepatic perfusion index was assessed. Results In control group, the hepatic, portal and total perfusion were 0.2823±0.0969 ml/min/ml, 1.1788±0.4004 ml/min/ml and 1.4563±0.4439 ml/min/ml, respectively. Hepatic perfusion index was 19.73%±5.81%. In cirrhosis group, the portal perfusion (0.6121±0.2544 ml/min/ml) and total perfusion (0.8426±0.3242 ml/min/ml) were decreased, while the hepatic perfusion (27.16%±12.75%) was a little bit increased although the difference was not statistically significant (P=0.065). Conclusion CT hepatic perfusion imaging can quantitatively estimate the parameters of hepatic blood flow.更多还原