【摘要】 目的　观察冠心病不同类型患者巨噬细胞集落刺激因子 (MCSF)的变化 ,探讨其对急性冠状动脉综合征(ACS)临床识别和预测的价值。方法　采用酶联免疫吸附法 (ELISA)检测 4 8例ACS、4 6例稳定型心绞痛 (SA)和 4 0例健康者血浆MCSF及白介素 6 (IL 6 )水平。结果　ACS患者MCSF和IL 6水平均显著高于SA患者 [MCSF :(4 6 3.4 8± 5 0 .99)ng/L vs(30 8.2 0± 4 7.75 )ng/L ;IL 6 :(9.0 2± 5 .12 )ng/L vs(4 .71± 1.73)ng/L ,P均 <0 .0 0 1]。SA患者MCSF水平显著高于健康对照者 [(30 8.2 0± 4 7.75 )ng/Lvs(2 82 .2 8± 2 3.35 ) ,P <0 .0 5 ]。进一步研究发现ACS患者MCSF水平与IL 6呈显著正相关 (rs=0 .4 87,P <0 .0 0 1)。结论　MCSF可能参与了ACS的发病过程 ,它可作为病情监测的指标更多还原

【Abstract】 Objective To investigate the difference of macrophage colony stimulating factor (MCSF) level in different subtypes of coronary heart disease and to explore the potential predicting factors for the acute coronary syndrome (ACS).Methods The study groups included 48 cases of ACS,46 stable angina (SA) and the control group induded 40 healthy subjects.Plasma level of MCSF and interlukin-6 (IL-6) was measured by means of enzyme-linked immunosorbent assay(ELISA).Results MCSF level was significantly higher in patients with ACS [( 463.48± 50.99) ng/L] than in those of SA [( 308.20± 47.75) ng/L,P< 0.001] and control group [( 282.28± 23.35) ng/L,P< 0.001].MCSF level was significantly higher in patients with SA [( 308.20± 47.75)ng/L] than in subjects of control [( 282.28± 23.35)ng/L,P< 0.05].IL-6 level was significantly higher in patients with ACS [( 9.02± 5.12) ng/L] than in those of SA [( 4.71± 1.73) ng/L,P< 0.001] and control group [( 3.63± 1.51) ng/L,P< 0.001].There was a positive correlation between MCSF and IL-6 in patients with ACS (r= 0.487,P< 0.001).Conclusion MCSF may involve in the pathogenesis of ACS,and it might be an available index for the severity of ACS.更多还原