【摘要】 目的 :探讨白细胞介素 8(IL 8)和白细胞介素 3(IL 3)在人类鼻息肉及鼻息肉病中的表达情况。方法 :采用免疫组织化学方法检测 31例鼻息肉患者 (鼻息肉组 )、2 6例鼻息肉病患者 (鼻息肉病组 )的息肉组织及 14例正常中鼻甲黏膜 (对照组 )中IL 8和IL 3的表达。结果 :IL 8在对照组、鼻息肉组及鼻息肉病组 3组间呈递增性表达 ,且每两组间差异均有统计学意义 (均P <0 .0 1) ;IL 3在对照组、鼻息肉组及鼻息肉病组 3组间亦呈递增性表达 ,且每两组间差异均有统计学意义 (均P <0 .0 1〉。结论 :IL 8是鼻息肉诸多病因之一 ,对鼻息肉病的复发起重要作用 ;IL 8在鼻息肉及鼻息肉病之间的不同表达提示二者的发病机制有本质差异 ;IL 3对鼻息肉组织中嗜酸性粒细胞的大量浸润起重要作用 ,也是鼻息肉与鼻息肉病二者发病机制差异中的一个重要因素更多还原

【Abstract】 Objective: To study the expression of IL-8 and IL-3 in human nasal polyp and polyposis.Method: Using immunohistochemical methods detect the expressions of IL-8 and IL-3 in 52 cases of middle turbinate、nasal polyp and nasal polyposis,and calculating the positive area percentages in each group. All datas were analysed with SNK test、Kruskal-Wallis test and Mann-Whitney test.Result:There were very significant differences between either two groups about the expressions of IL-8.There were significant differences between either two groups about the expressions of IL-3.Conclusion:IL-8 is not only one of the causes in nasal polyp, but also plays an important role in the recurrence of nasal polyposis.The expression of IL-8 in polyp is different from that in polyposis,it indicatethat polyp and polyposis have different mechanism.IL-3 is important for the accumulation of eosinophil and is a key factor in the mechanism of polyposis.更多还原