【摘要】 目的 :探讨羊胎素增进大鼠体重作用及复方羊胎素对抗羊胎素体重增长的作用 .方法 :采用预防性肥胖模型法 ,将大鼠分为 6组 :肥胖模型组 (A)、羊胎素组 (B)、复方羊胎素 1～ 4组 (C1～ 4) ,在喂饲营养饲料的基础上 ,对各实验组分别给予不同受试物 ,连续喂养 4 2d ,观察大鼠体重、增重、进食量、食物利用率、体内脂肪、脂 /体比 ,主要脏器的病理改变及脏器系数 .结果 :B组大鼠体重、增重显著高于A及C2 、C3 组 (P <0 0 5 ) ,进食量极显著高于、食物利用率极显著低于A及C1～ 4组 (P <0 0 1) .B组体内脂肪极显著高于A及C2 、C3 组 (P <0 0 1) ,显著高于C1、C4(P <0 0 5 ) ,脂 /体比极显著高于A组 (P <0 0 1) ,显著高于C1～ 4组 (P <0 0 5 ) .C4组肝及脾的脏器系数极显著和显著高于A及各实验组 (P <0 0 1,P <0 0 5 ) .结论 :羊胎素通过增进食欲促进大鼠体重增长及体内脂肪堆积 ,复方羊胎素 2和 3组能有效控制羊胎素所致体重增长及体内脂肪堆积 ,复方羊胎素 3组致肝、脾增大原因待查 .更多还原

【Abstract】 Objective: To investigate the effect of sheep placental extract on weight gain o f adult rat, and compound sheep placental extract against the weight gain induced by sheep placental extract. Methods: The obese model rats were rand omly divided into 6 groups: obese rat model group (A), sheep placental extract ( B), compound sheep placental extract (C 1～4). In the end of the experiment (42 da ys), observing body weight, weight gain, food intake, food efficiency, carcass f at content, relative weight of fat/body, pathological changes of main organs and organs relative weight. Results: Body weight and weight gain of group B are hig her than of group A, C 2 and C 3 (P<0 05); food intake is si gnificantly higher and food efficiency is significantly lower than group A and C 1～4 ( P<0 01); carcass fat content is significantly higher than group A, C 2 and C 3 (P <0 01), and higher than group C 1 and C 4 (P<0 05); the relative weight of fat /body is significantly higher than group A (P<0 01), and higher than group C 1～4 (P<0 05). On group C 4, the organs relative weight of liver and spleen is significantly higher than gro up A (P<0 01), and higher than group B and C 1～3( P<0 05). Conclusions: (1) shee p placental extract can increase rat weight and carcass fat content by stimulati ng appetite; (2) the group C 2 and C 3 of compound sheep placental extract can dec rease the weight and carcass fat content induced by sheep placental extract; (3) the group C 3 of compound sheep placental extract can result in weight gain o f liver and spleen.[更多还原