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海洛因所致肾损害与横纹肌溶解症
Heroin-induced Renal Damage and Rhabdomyolysis
【摘要】 目的 :通过实验研究揭示海洛因成瘾与由之所致肾损害及横纹肌损害之间的关系 .方法 :应用免疫组织化学及透射电镜扫描的研究方法 ,对 11例海洛因成瘾尸体肾脏及腓肠肌组织进行透射电镜观察 .结果 :肾组织免疫组织化学研究 ,11例中 6例检出肌红蛋白成份 ;对上述尸体肾脏及腓肠肌进行透射电镜扫描观察 ,不同程度地显示了一定的形态学特征 .结论 :肾组织中肌红蛋白的检出 ,揭示了海洛因滥用及其所致肾损害和横纹肌损害之间的关系 ,指出海洛因所致横纹肌溶解症的存在及其与海洛因成瘾者临床肌痛之间的关系 .强调在海洛因所致横纹肌溶解症死者的肾脏组织中 ,如若采用免疫组织化学的方法可检出肌红蛋白的成份 .对海洛因所致其它脏器组织的形态学改变及其成因进行了讨论
【Abstract】 The renal tissue in eleven heroin addicts was studied by immunohistochemical technique and the myoglobin was demonstrated in six of them. The kidney, soleus and myocardium were studied using transmission electron microscopical technique (TEM) as well. The presence of myoglobin in kidney and the related changes on striped muscle documented the relation between the renal damage and rhabdomyolysis in heroin addiction. The effects of heroin on other tissues were observed grossly and microscopically.
【Key words】 Morphological observation; Rhabdomyolysis; Myoglobin; Immunohistochemistry; Electron microscopy; Striped muscle; Kidney; Heroin;
- 【文献出处】 昆明医学院学报 ,Academic Journal of Kunming Medical College , 编辑部邮箱 ,2004年01期
- 【分类号】R595.5
- 【被引频次】5
- 【下载频次】94