Objective The method of three-dimension reconstruction with small data set was presented and then was used to investigate location and shape of the brain nucleus.Methods Twenty adult whole brains from cadavers without gross pathologic changes were collected and were cut into a series of slices of 2 mm in thickness. The red nucleus, lentiform nucleus were reconstructed with the method based on surface modeling method. The volume and location of these reconstructed nuclei were measured by programs on computer...