【摘要】 为观察普罗布考降低血浆内皮素 1对高血压病患者早期肾损害的影响 ,将 12 0例高血压病患者随机分为高血压对照组和抗氧化治疗组 ,分别予长效心痛定、长效心痛定加普罗布考治疗 12周。另设正常对照组。比较治疗前后血脂、内皮素 1、血、尿 β2 微球蛋白及尿微量白蛋白的变化。结果发现 ,高血压病患者存在内皮功能和早期肾功能损害 ;降压治疗后 ,内皮素 1、甘油三酯、低密度脂蛋白、血、尿 β2 微球蛋白及尿微量白蛋白明显下降 ,差异有显著性 (P <0 .0 5 ) ;而抗氧化治疗组上述指标下降更明显 (P <0 .0 1)。抗氧化治疗较单纯降压治疗更能改善血管内皮功能 ,逆转高血压病患者的早期肾损害 ,提示内皮功能损害可能参与了高血压病患者的肾损害。更多还原

【Abstract】 Aim To observe the effect of anti-oxidizer’s improving vascular endothelial function on the early damage of the kidney in hypertension patients. Methods 120 subjects were randomly divided into pressure-lowering control group and anti-oxidizing treating group. Ultralente-nifedipine and probucol in addition to ultralente-nifedipine together were respectively given to the two groups for 12 weeks, and the changes of blood lipoprotein, endothelins(ET), β 2-MG in blood and urine and Alb in urine before treatment with those after treatment. Results First, there were the damage of endothelial function and the early damage of the kidney. Second, there was obvious decrease in ET-1, low-density cholesterol, β 2-MG in blood and urine and Alb in urine after treatment, and the difference was significant (P<0.05); while the above indexes decreased more remarkably in the anti-oxidizing treating group (P<0.01). Conclusions Anti-oxidizing treating can improve vascular endothelial function and diverse the early damage of the kidney in the hypertension patients better than only pressure-lowering treatment. It was pointed out that endothelins damage possibly had some association with the damage of the kidney in the hypertension patients.更多还原