【摘要】 目的研究皮下注射粒细胞集落刺激因子(G-CSF)动员剂及捐献外周血造血干细胞(PBSC)对无关健康供者的影响。方法28名外周血造血干细胞捐献者在采集前1~5天,皮下注射粒细胞集落刺激因子5mg/kg,连续1~5天皮下注射,观察G-CSF动员和采集时供者出现的不良反应;并对供者在G-CSF动员前、外周血干细胞采集后的健康状况及血常规进行分析。结果经G-CSF动员并采集了干细胞的28名供者中,23名供者(81.4%)未出现任何不良反应;5名供者(18.6%)出现轻微不良反应,并于采集时或采集后一周内自行消失。28名供者捐献造血干细胞后,经健康状况咨询和体格检查,结果未见异常。供者的血常规大多在捐献的15天后恢复到基础水平,与G-CSF动员前无显著性差异(P>0.05);但血细胞计数基础值偏低的供者,采集后白细胞和血小板恢复较慢。结论本研究通过对供者捐献造血干细胞后的体检、血常规检测和随访,结果表明无偿捐献造血干细胞对供者是安全的。更多还原

【Abstract】 Objective To investigate the effect of granulocyte colony-stimulating factor (G-CSF) mobilization and peripheral hematopoiedtic stem cell donation on healthy unrelated donors. Methods 28 donors received G-CSF at 5mg/kg on days 1～5 before peripheral blood stem cell collection, their clinical symptoms were observed. Peripheral blood cell count and physical examination were made for each donor at a regular interval, and analysed the difference between the cell counting before G-CSF mobilization and the counting after PBSC donation. Results In 28 donors having received G-CSF mobilization and peripheral blood stem cell collection, 23 donors (81.4%) had not any side-effect while giving PBSC; 5 donors(18.6%) only had mild untoward effects and all the untoward effects disappeared within one week after donating PBSC. According to the results of healthy inquiry and physical examination, 28 donors donated PBSC were all in normal health. For most of the individuals who having donated PBSC, the counts of peripheral blood cell returned to baseline counts in 15 days later; but for the donors whose peripheral blood cell counts were lower than normal counts, the counts of white cells and platelet cells get back slowly. Conclusion The results of physical examination and peripheral blood cell count and health inquiry indicate that G-CSF mobilization and peripheral blood stem cell donation is safe for PBSC unrelated donors.更多还原