【摘要】 通过4 取代苯酮的α 溴化反应合成医药中间体α 溴 4 取代苯酮。选择溴化铜在乙酸乙酯和氯仿混合溶剂中对4 甲氧基苯乙酮、4 羟基苯乙酮、4 羟基苯丙酮、4 羟基苯戊酮、4 苄氧基苯乙酮、4 苄氧基苯丙酮和4 苄氧基苯戊酮溴化2～3h,分别得α 溴 4 甲氧基苯乙酮、α 溴 4 羟基苯乙酮、α 溴 4 羟基苯丙酮、α 溴 4 羟基苯戊酮、α 溴 4 苄氧基苯乙酮、α 溴 4 苄氧基苯丙酮和α 溴 4 苄氧基苯戊酮,收率82 6%～97 5%。α 溴化产物的结构经1HNMR,IR确证。更多还原

【Abstract】 α -Bromo- 4-methoxyacetophenone, α -bromo- 4-hydroxyacetophenone, α -bromo- 4-hydroxypropiophenone, α -bromo- 4-hydroxyvalerophenone, α -bromo- 4-benzyloxyacetophenone, α -bromo- 4-benzyloxypropiophenone and α -bromo- 4-benzyloxyvalerophenone were synthesized by α -bromination of 4-methoxyacetophenone,4-hydroxyacetophenone,4-hydroxypropiophenone,4-hydroxyvalerophenone,4-benzyloxyacetophenone,4-benzyloxypropiophenone and 4-benzyloxyvalerophenone respectively with cupric bromide in AcOEt-CHCl₃ in 82.6%～97.5 % yield.Structures of the products were confirmed by IR and ¹HNMR.更多还原