【摘要】 目的　探讨抑郁症的认知障碍的特点。方法　对93例抑郁症病人采用事件相关电位 P300及韦氏智力量表与对照组比较。结果　抑郁组P300电位成分中N2、P3潜伏期延长,P3波幅降低,与 对照组比较存在显著性差异(t=2.84,3.87,8.64,P均<0.01);抑郁组与对照组比较在领悟、数字广度、 词汇、编码、填图各分测验有显著差异(t=2.83,5.25,2.74,2.76,2.64,P均<0.01);N2潜伏期延长与 领悟、填图显著相关,P3潜伏期延长与领悟、数字广度、编码显著相关,P3波幅与领悟显著相关。结论 　提示抑郁症存在有广泛的认知障碍。更多还原

【Abstract】 Objective: To investigate characteristic of the cognitive disorder in depression. Methods: 93 patients with depression and 54 normal persons were measured by P 300 and Wechsler Intelligence Scale. Results: The latencies of N 2、P 3 were prolonged significantly and amplitude of P 3 was reduced significantly in depression compared with the control group(t=2.84,3.87,8.64,P<0.01), the Comprehension、Digit span、Vocabulary、Coding、Picture completion of test were reduced significantly in depression compared with those of control group(t=2.83,5.25,2.74,2.76,2.64 P<0.01); The prolonged latency of N 2 were correlated significantly with the reduced scores of Comprehension、Arithmetic、Picture completion in depression, the prolonged latency of N 2 were significantly correlated with the reduced scores of Comprehension、Digit span、Coding、Picture arrangement in depression,the reduced amplitude of P 3 were significantly correlated with the reduced scores of Comprehension in depression. Conclusion: The patients with depression had extensive cognitive deficits.更多还原