【摘要】 目的　探讨氯丙嗪和氯氮平对首发精神分裂症血糖水平的影响。方法　对 16 0例首发精神分裂症患者随机给予氯丙嗪或氯氮平治疗 ,于治疗前及治疗 12周、2 6周、5 2周末分别测定一次空腹血糖。结果　首发精神分裂症患者治疗前合并高血糖者占 8 75 % ,氯丙嗪治疗 5 2周末时血糖水平增高 ,而氯氮平治疗 12周后血糖水平即增高 ,治疗 2 6周时 ,氯氮平组合并高血糖者显著高于氯丙嗪组 (χ2=4 81,P =0 0 3)。结论　氯氮平治疗期间应定期监测血糖。更多还原

【Abstract】 Objective: To explore the influence of chlorpromazine and clozapine to blood glucose in first-episode schizophrenia. Methods: 160 first-episode schizophrenic patients were treated randomly with chlorpromazine or clozapine. Blood glucose on an empty stomach was assessed prior and after 12 weeks, 26 weeks, 52 weeks treatment. Results: First-episode schizophrenia concomitand with hyperglycemia accounted for 8.75% prior to treatment, blood glucose of patients with chlorpromazine were evelated after 52 weeks treatment, blood glucose of patients with clozapine were elevated after 12 weeks treatment, the percentum of schizophrenics merged hyperglycemia with clozapine was significantly higher than chlorpromazine after 26 weeks treatment (χ 2=4.81, P=0.03). Conclusion: The blood glucose level of schizophrenic patients with clozapine should be monitored regularly.更多还原