【摘要】 突触体素是一种突触前囊泡膜上的主要膜整合糖蛋白 ,作为一种神经终末的可靠标记物 ,为监测突触密度提供了一种新方法。本文对其分子特征、分布、功能及在癫痫、阿尔茨海默病、精神分裂症和脑损伤等脑疾病中的变化和意义进行综述。更多还原

【Abstract】 Synaptophysin, an integral membrane gl yc oprotein of presynaptic vesicles, has been proved to be a useful marker for quan titative synaptic terminals. It provides a new method to determine the density o f synapses. In this paper, the author summarized the molecular character, distri bution, functions of synaptophysin and its concentration changes and significanc es in the pathogenesis of epilepsy, Alzheimer ’s disease, Schizophrenia and brai n damage.更多还原