【摘要】 AQP8是 1997年以来被鉴定的哺乳动物水通道蛋白家族成员之一 ,主要分布于肝细胞、胰腺腺泡细胞、消化道上皮细胞、唾液腺腺泡细胞、睾丸精子细胞、胎盘、支气管上皮细胞和支气管腺的肌上皮细胞以及肾近曲小管、集合管上皮细胞的细胞内囊泡和顶质膜。能够特异性通透水分子 ,受cAMP等因素调节 ,可在细胞内囊泡与细胞顶质膜之间穿梭。可能参与胰液、胆汁及唾液的分泌、排泄物的脱水、精子成熟和受精以及肾脏水的重吸收等生理过程。更多还原

【Abstract】 AQP8 is one of the members of the mammali an water channel family proteins that have been identified since 1997. It is mainl y distributed in hepatocyte, acinal cell of exocrine pancreas and saliva gland, epithelium of gastrointestinal tract, spermatid of testis, and the epithelium of placenta and bronchus, the myoepithelial cell of the bronchus gland and the cel lular vesicle and the apical membrane of the epithelium of the kidney proximal t ubules and collecting tract. AQP8 is permeable to water specifically. It can shu ttle between the intracellular vesicle and the cell apical membrane by the regul ation of cAMP. It might participate in the process of the secretion of pancreas fluid, bile and saliva and the dehydration of the excrement, spermatogenesis an d the reabsorption of the water in kidney.更多还原