【摘要】 胰高血糖素样肽GLP 1和GLP 2由小肠和大肠的内分泌细胞产生并分泌。GLP 2通过对胃的动力作用和营养吸收作用保持小肠粘膜上皮的完整 ,对小肠损伤修复等均有重要的调节作用 ,GLP 2在循环中二肽肽酶Ⅳ (DPIV)的作用下氨基末段迅速裂解失去活性 ,并通过肾脏清除。利用这些肽对营养吸收和能量平衡及在糖尿病动物模型和小肠疾病的作用 ,可供临床应用并治疗人类的疾病更多还原

【Abstract】 The glucagons-like peptides-1(GLP-1) and GLP-2 are produced and secreted in enteroendocrine L cells of the small and large intestines. GLP-2 maintains the integrity of the intestinal mucosal epithelium via effects on gastric motility and nutrient absorption, has regulatory effect on the repair of the damaged intestine. GLP-2 is rapidly inactivated in the circulation as a consequence of amino-terminal cleavage by the enzyme dipeptidyl peptidase IV (DP IV). The actions of these peptides on nutrient absorption and energy homeostasis and the efficacy of GLP-2 in animal models of diabetes and intestinal diseases, suggest that analogs of these peptides may be clinically useful for the treatment of human diseases.更多还原