【摘要】 在急、慢性疾病中 ,细胞释放的炎症介质可以活化多种信号转导级联反应 ,丝裂原活化蛋白激酶 (MAPK)信号转导通道在招募白细胞于炎症部位聚集起着重要的作用。同时 ,p38MAPK异构体的活化可以激活致炎细胞因子 ,而后刺激白细胞活化。然而 ,p38MAPK引起的白细胞招募这一系列的功能过程包括 :粘附、游走和效应器的功能如氧化爆发以及 p38MAPK介导的复杂细胞因子网络在炎症中的作用仍有待研究。针对减少炎症介质产生和以 p38MAPK为治疗靶点的研究正在进行中 ,不远的将来可能会成为治疗炎症疾病的新策略。更多还原

【Abstract】 Inflammatory mediators releasing during acute and chronic diseases can activate multiple intracellular signals inducing cascades of the mitogen-activated protein kinase(MAPK) signalling transduction pathway. MAPK plays a significant role in the recruitment of leukocytes to the inflammation sites. Stimulation of leukocytes by pro-inflammatory cytokines is known to activate the MAPK isoform p38. However, the consequences of p38MAPK activation during leukocyte recruitment, adhesion, migration, functions of effector(oxidative burst), and the network of cytokines mediated by p38MAPK are all investigated for further elucidation. Specific p38 inhibitors in reducing the production of inflammatory mediators and providing more effective treatment are now being developed.更多还原