【摘要】 目的 :探讨乳腺非霍奇金淋巴瘤 (NHL)的临床细胞学及组织学特点。　方法 :运用细针吸取细胞学、组织学及免疫组化标记技术对 12例乳腺NHL进行观察研究和鉴别诊断 ,同时对其临床资料进行分析。　结果 :12例乳腺NHL中 3例为T细胞性 ,9例为B细胞性。T细胞淋巴瘤细胞学瘤细胞多呈弥漫散在分布 ,瘤细胞呈卵圆形、多形性 ,部分细胞核畸形、扭曲 ,核膜薄 ,核染色质分布均匀 ,可见核仁 ;组织学见部分瘤细胞围绕血管 ,形成“嗜血管”现象。B细胞淋巴瘤细胞学和组织学瘤细胞呈弥漫性分布 ,瘤细胞呈圆形或椭圆形 ,核染色质凝块状或粗颗粒状 ,可见核仁及核分裂象及“淋巴上皮病变”。免疫表型 :T细胞性CD3、CD4 3及CD4 5RO阳性 ;B细胞性CD2 0、CD74和CD79a阳性。T、B细胞性NHLCK、EMA、ER和PR均阴性。　结论 :乳腺NHL少见 ,为提高诊断准确率 ,多种方法检查有其互补性。更多还原

【Abstract】 Objective:To investigate the clinic-cytology and histopathology of non-Hodgkin lymphoma (NHL) in breasts. Mothods:Twelve cases of NHL of the breast were studied by fine-needle aspiration biopsy (FNAC), histopathology and immunohistochemistry, and whose clinical data were analysed at the same time. Results:In 12 cases of NHL, 3 cases were T-cell NHL and 9 cases were B-cell NHL. Cytologically, the T-cell NHL cells were mostly arranging in diffuse patterns. The tumor cells were oval and pleomorphism. Some of them had distorted nucleus and thin nuclear envelope.The nucleus showed irregular course chromatin and visible nueleoic. Histopathologically, some of the tumor cells distributed around the blood vessels, and there was an obvious phenomenon of “blood-vessel-closing”. B-cell lymphoma cells were arranginy in diffuse pattern, and showed round and ellipse in shape with a clot and course granular chromatin and visible nueleoic and karyoknesis. Lymphoepithelia lesions were seen. Immunohistochemistry showed that CD3, CD43, and CD 45RO in T-cells NHL were positive.CD20, CD74 and CD79a in B-cells NHL were negative. CK, EMA, ER and PR in NHL were all negative. Conclusion:NHL of breast is extremely rare, and its definite diagnosis depends on various examination methods.更多还原