【摘要】 目的 :探讨四羟基苯基介导光动力治疗对肿瘤的杀伤效应及其对肺癌鼠存活期限的影响。方法 :接种Louis肺癌的雄性昆明小鼠3 0只随机分为实验组和对照组各 15只 ,用光动力疗法作用于实验组 ,对照观察两组存活期。结果 :两组小鼠生存分析曲线差异有显著性P <0 .0 5 ,实验组荷瘤鼠平均生存时间为 3 2 .62天 ,对照组为 2 3 .12天。结论 :证明四羟基苯基介导光动力治疗对肿瘤组织具有杀伤和抑制作用 ,可延长实验组荷瘤鼠的存活期。结果为将其应用于临床治疗恶性肿瘤提供依据。更多还原

【Abstract】 Objective:In order to investigate the mechanism of lethal effect of Photodynamic therapy by mTHPC for tumour and the survival effect of tumourbearing mice .Methods:The study was carried out with 30 Kunming mice inoculated by Louis lung cancer,which were treated with Photodynamic therapy.The lethal effect and survival effect of tumourbearing mice were examined and compared between the experimental group and control group.Results:The survival period of experimental group and control group was averagely 32.62 days and 23.12 days respectively.There was a significant difference in survival curve. Conclusion:It is confirmed that Photodynamic therapy has inhibiting effect and lethal effect for tumour.It may prolong the survival period of tumour-bearing mice.更多还原