【摘要】 羟脯氨酸的含量是反映胶原纤维变化的敏感生化指标。本文利用昆明小鼠作为动物模型,研究不同能量的595nm脉冲染料激光对皮肤羟脯氨酸含量的影响。20只昆明小鼠随机分为两组,1个实验组和1个对照组。三种能量的激光各照射5次,每次间隔3天,光斑有10%的重叠。照射后测皮肤羟脯氨酸含量的变化,SPSS进行数据分析。8J/cm2、10J/cm2和12J/cm2组羟脯氨酸含量分别比对照组增加39%、50%和58%(p<0.05),12J/cm2能量组的效果最好,但他们之间没有统计学上的显著差异,表明595nm的脉冲染料激光照射能明显增加皮肤羟脯氨酸的含量,用于非损伤嫩肤治疗是有效的。更多还原

【Abstract】 Hydroxyproline is the sensitive biochemical marker reacting collagen fibres changes. Using KM mice as animal model,the effects of different energy’s pulsed dye laser to hydroxyproline in the skin of mice were studied. Twenty KM mice were randomly divided into two groups,one laser irradiation group,and one control group. Three different energy levels were applied for five times at a interval of three days,with 10% overlap. All experimental data were analyzed using SPSS11.5 statistical software. The hydroxyproline in the skin irradiated by 8 J/cm~2,10 J/cm~2 and 12 J/cm~2 showed 39%、50% and 58%(p<0.05)increase respectively compared to the control group,among which 12 J/cm~2 energy had the greatest effect. No statistical significance was found between them. 595 nm pulsed dye laser can increase obviously the quantity of its hydroxyproline and can be used as a safe and effective method for noninvasive wrinkle reduction.更多还原