【摘要】 目的　探索妊娠期肝内胆汁淤积症 (ICP)与孕产妇及其子代健康的关系。方法　对合肥市西市区妇幼保健所一年中 2 0 0 7例孕产妇妊娠期、分娩期和产褥期的健康资料及新生儿的健康状况资料进行分析。结果　该社区 ICP发生率为 12 .31%。 ICP组剖宫产率、产后出血率分别为4 6 .96 %和 6 .88% ,均高于对照组 (34.94 %、2 .95 % ) ,且差异有统计学意义。 ICP组胎儿窘迫率为2 5 .5 1% ,高于对照组的 16 .88% ,差异有统计学意义。依据 Apgar评分 ,ICP组和对照组新生儿重度窒息分别为 3.0 0 %、1.19% ,差异有统计学意义。结论　 ICP不仅增加孕产妇剖宫产和产后出血的危险 ,而且与胎儿窘迫和新生儿重度窒息相关联更多还原

【Abstract】 Objective To determine the relationship of intrahepatic cholestasis of pregnancy (ICP) to maternal and child health. Methods In the study, 2 007 pregnant women were involved. A case-control study was employed to analyze their perinatal data and neonatal data. Results The incidence of ICP was 12.31% in this district. The rates of cesarean and postpartum hemorrhage were 46.96% and 6.88% respectively in ICP group; both were higher than non-ICP group. The rate of fetal distress in ICP group was 25.51%, significantly higher than control group; the rate of asphyxia of newborn was significantly higher than non-ICP group. Conclusions ICP not only increases the risk of cesarean and postpartum hemorrhage but also is related with fetal distress and asphyxia of newborn.更多还原