【摘要】 目的 :探讨牛珀至宝微丸对内毒素休克大鼠脑诱导型一氧化氮合酶 (InducibleNitricOxideSynthase,iNOS)表达的影响。方法 :静脉注射内毒素 1 5mg/kg、腹腔注射D -氨基半乳糖 (D -GaLN) 1 0 0mg/kg造成内毒素休克模型 ,免疫组化方法检测iNOS在脑区的表达。结果 :内毒素组iNOS阳性细胞分布于大脑皮质、纹状体、脑干、小脑等。而牛珀至宝微丸能明显降低内毒素所致iNOS表达 ,二者间比较 ,差异有显著性。结论 :牛珀至宝微丸治疗内毒素休克脑损伤与下调iNOS表达相关。更多还原

【Abstract】 Objective: to research the effect of Niupozhibao Weiwan (NW) on cerebral inducible nitric oxide synthase (INOS) expression. Methods: by means of intravenous injection of endotoxin 1.5 mg/kg and abdominal injection of D-GaLN 100 mg/kg, models of endotoxic shock were made, and INOS expression in brain was detected by immunohistochemical method. Results: INOS positive cells of endotoxin group distributed over cerebral cortex, striate body, brain stem and cerebellum etc. NW could decrease INOS expression induced by endotoxin, and the difference between them was significant. Conclusion: NW treating brain injuries by endotoxic shock has relationship with decreased INOS expression.更多还原