【摘要】 目的　为了解农村 18岁以下儿童、青少年乙肝疫苗普种前基础资料 ,提出相应的预防策略。方法　采用随机的方法 ,在我省选择了普种前的 5县 12村 18岁以下儿童、青少年 32 85例进行乙肝疫苗接种率及乙肝病毒感染率 (HBV)调查 ,对血清样本检测HBsAg、抗 -HBc、抗 -HBs。结果　乙肝疫苗接种率为 2 4 .78% (814 /32 85 ) ,新生儿乙肝疫苗接种率为 2 2 .80 % (74 9/ 32 85 )。接种乙肝疫苗者的HBsAg、抗 -HBc阳性率明显低于无接种乙肝疫苗者 ;1992～ 1998年出生的儿童HBV感染率为 2 1.6 % ,明显低于 1984～ 1991年出生的儿童乙肝HBV感染率 (4 3.37% )和 1980～ 1983年出生的儿童HBV感染率 (5 0 .14 % )。结论　提高农村新生儿的乙肝疫苗接种率 ,是降低我省乙肝病毒流行的关键更多还原

【Abstract】 Objective In order to collect the data for a new preventive policy of hepatitis B as well as a baseline prior to popularizing hepatitis B vaccine in the children under 18 ages in Henan province.Methods an investigation of coverage and protection of hepatitis B vaccine was conducted. 3285 subjects under 18 years of ages from 12 villages in 5 counties were sampled randomly.Blood was collected for HBsAg,anti-HBc and anti-HBs detection. Results The coverage of hepatitis B vaccine was 24.78%(814/3285) The neonate uaccine coverage rate 22.8%(749/3285).The positive rates of HBsAg, and Anti-HBc in vaccines was lower significantly than those in non-vaccinees. The prevalence of HBV in the children(21.6%) born in 1992 to 1998,have significantly declined comparing to it in the children (43.37%) born in 1984 to 1991,the period that hepatitis B vaccine was used sporadically,and in the children (50.14%) born in 1980 to 1983 when hepatitis B vaccine was unavailable. Conclusion The coverage of hepatitis B vaccine in the newborn is a critical factor for reducing the prevalence of HBV.更多还原