【摘要】 目的　探讨一氧化氮合酶抑制剂L NNA对福尔马林实验大鼠脑一氧化氮合酶表达的影响。方法　应用免疫组织化学ABC法研究了nNOS、iNOS在福尔马林大鼠脑内的表达。结果　在福尔马林实验大鼠不同脑区 ,nNOS和iNOS表达较强。一氧化氮合酶抑制剂L NNA可抑制福尔马林实验大鼠脑nNOS、iNOS的表达 ,NO生成减少。结论　一氧化氮合酶抑制剂L NNA可通过抑制一氧化氮合酶作用 ,参与伤害性痛觉调制。一氧化氮在脑的痛觉调制过程中起重要作用。更多还原

【Abstract】 Objective To explore the effect of nitric oxide synthase inhibitor L-NNA on the expression of nNOS and iNOS in the brain of formalin test rats.Methods The expression of nNOS and iNOS in the formalin rat brain was examined by a sensitive immunohistochemical method.Results In the brain of formalin test rats,nNOS and iNOS expressed strongly.Nitric oxide synthase inhibitor L-NNA inhibited the expression of nNOS and iNOS in the brain of formalin rats,reduced the production of nitric oxide.Conclusion NOS inhibitor L-NNA inhibits the effect of NOS and nitric oxide may play an important role in pain modulation in the brain.更多还原