【摘要】 目的　研究胰岛素样生长因子 1(IGF 1)在良恶性胸腔积液表达的水平及临床意义。方法　对 33例良性胸腔积液患者和 32例恶性胸腔积液患者采用双抗体夹心法检测胸腔积液IGF 1,并与胸液癌胚抗原 (CEA)的含量测定对比。结果　恶性胸腔积液组IGF 1水平 ( 110 .2 0nmol/L± 2 0 .5 9nmol/L)显著高于良性组 ( 76 .70nmol/L± 18.95nmol/L) ,P <0 .0 0 1。胸腔积液IGF 1含量测定对恶性胸腔积液的诊断效能略差于CEA。结论　胸腔积液IGF 1的检测在良恶性胸腔积液的鉴别诊断中有一定的临床意义。CEA、IGF 1的联合检测有助于临床诊断更多还原

【Abstract】 Objective To investigate the diagnosis value of insulin like growth factor 1(IGF 1) in benign and malignant pleural effusion compared with carcinoembryonic antigen(CEA).Methods IGF 1 and CEA were analyzed by ELISA in 33 cases with benign pleural effusion and 32 cases with malignant pleural effusion.Results The concentration of IGF 1 were significantly higher in malignant pleural effusion(110.20±20.59nmol/L) than that in benign group(76.70±18.95nmol/L),P<0.001.IGF 1 was slightly less valuable than CEA in diagnosis of malignant pleural effusion.Conclusion In pleural effusions IGF 1 may be an important indicator to help to differentiate between benign pleural effusions and malignant pleural effusions.更多还原