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NMR and Pattern Recognition Studies on the Acute Biochemical Effects of Lu(NO33

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【作者】 吴惠丰张晓宇冯江华孙国英吴亦洁裴奉奎聂毓秀

【Author】 WU, Hui-Fenga ZHANG, Xiao-Yua FENG, Jiang-Huaa SUN, Guo-Yinga WU, Yi-Jiea PEI, Feng-Kui*, a NIE, Yu-Xiub a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China b College of Basic Medicine Science, Jilin University, Changchun, Jilin 130021, China

【机构】 Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022ChinaCollege of Basic Medicine ScienceJilin UniversityJilin 130021China

【Abstract】 Pattern recognition methods were applied to the analysis of 600 MHz H NMR spectra of urine from rats dosed 1 with compounds that induced organ-specific damage in the liver and kidney. Male Wistar rats were separated into groups (n=4) and each was treated with one of following compounds: HgCl2, CCl4, Lu(NO3)3 and Changle (a kind of rare earth complex mixed with La, Ce, Pr and Nd). Urine samples from the rats dosed with HgCl2, CCl4 and Lu(NO3)3 were collected over a 24 h time course and the samples from the rats administrated with Changle were gained after 3 months. These samples were measured by 600 MHz NMR spectroscopy. Each spectrum was data-processed to provide 223 intensity-related descriptors of spectra. Urine spectral data corresponding to the time intervals, 0—8 h (HgCl2 and CCl4), 4—8 (Lu(NO3)3) h and 90 d (Changle) were analyzed using principal compo- nent analysis (PCA). Successful classification of the toxicity and biochemical effects of Lu(NO3)3 was achieved.

【基金】 Project supported by the National Natural Science Foundation of China (No. 29890280).
  • 【文献出处】 Chinese Journal of Chemistry ,中国化学(英文版) , 编辑部邮箱 ,2004年08期
  • 【分类号】O657.2;O614
  • 【下载频次】4
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