【摘要】 目的　探讨 FHIT蛋白表达在宫颈癌发生发展过程中的作用。方法　用免疫组化 SP法对 2 2例正常宫颈、35例宫颈上皮内瘤样病变 (CINs)及 6 0例原发性浸润性宫颈癌组织分别进行 FHIT蛋白表达的检测。结果　正常宫颈组织鳞状上皮、低级别 CINs、高级别 CINs、宫颈癌 FHIT蛋白降低或缺乏表达率分别为 0 % (0 / 2 2 )、2 0 %(4 / 2 0 )、5 3.3% (8/ 15 )、81.7% (4 9/ 6 0 ) ,P<0 .0 5 ;在高、中、低分化的浸润性宫颈癌中 ,FHIT蛋白降低或缺乏表达率分别为 6 0 .0 % (6 / 10 )、70 .0 % (14 / 2 0 )、96 .7% (2 9/ 30 ) ,P <0 .0 5 ;有淋巴转移者 FHIT蛋白表达异常率为90 .9% (10 / 11) ,高于非淋巴转移者的 79.6 % (39/ 4 9)。结论　在高级别 CINs中 FHIT蛋白的丢失可作为一个判定其有可能发展为浸润性癌的有用指标 ,FHIT蛋白表达状况可反应宫颈癌细胞的临床特性和该疾病的预后。更多还原

【Abstract】 Objective To explore the relationship between reduction of FHIT expression of fragile histidine triad (FHIT) and the development of cervical carcinoma. Methods Expression of the FHIT product was detected by immunohistochemistry in 22 normal cervices and 35 cervical intra-epithelial neoplasias (CINs) as well as 60 primary invasive cervical carcinomas. Results The rates for loss or reduction of expression of FHIT protein in the squamous epithelium of normal cervices, CINⅠ-Ⅱ, CINⅢ and noninvasive carcinoma and invasive cervical carcinoma were 0%(0/22),20%(4/20),53.3%(8/15),81.7%(49/60) respectively(P<0.05). Among the well differentiated, intermediately differentiated and poorly differentiated invasive cervical carcinoma, the rates for loss or reduction of expression of FHIT protein were 60.0% (6/10), 70.0% (14/20), and 96.7% (29/30) respectively(P<0.05). The rate of the impaired FHIT protein expression in the invasive cervical carcinoma with lymph node metastasis (90.9%) was higher than that without lymph node metastasis (79.6%). Conclusion The impaired FHIT protein expression might be a useful indicator in identifying the possibility of the progression of advanced CINs into invasive cervical carcinoma.FHIT protein expression might indicate the clinical characteristic of cervical carcinoma cells and the prognosis of cervical carcinoma.更多还原