【摘要】 合成了一种新的环糊精衍生物单 6 氧 (对硝基苯甲酰基 ) β 环糊精 (NBCD) .该化合物与 1 萘甲酸(NA)在KCl/HCl缓冲水溶液 (pH =1.5,0 .1mol/dm3)中形成 1∶1包合物 ,15℃时的包合常数由稳态荧光测定 ,结果表明 ,NBCD可以和 1 萘甲酸形成稳定的包合物 ,与 β 环糊精相比 ,稳定常数增加 9倍左右 .同时 ,时间分辨荧光得到了NBCD与其它给电子的萘的衍生物的包合常数 .结果表明 ,在 β 环糊精的 6位引进对硝基苯甲酰基能够显著增强其包合能力 ,使NBCD能够与萘的衍生物形成稳定的主 客体包合物更多还原

【Abstract】 To enhance the binding ability of β-cyclodextrin w ith naphthalene derivatives, a hydrophobic group to the rim of β-cyclodextrin was added and the new β-cyclodextrin compound—mono-6-p-nitrobenzoyl- β-cyclodextrin was synthesized. Its binding ability for 1∶1 inclusio n complexation with 1-naphthoic acid was evaluated in the KCl/HCl buffer soluti on (pH=1.5, 0.1 mol/dm 3) at 15℃ by the spectrofluormetric titration. The resu lts obtained indicated that mono-6-p-nitrobenzoyl-β-cyclodextrin could strongly include 1-naphthoic acid in aqueous solution; the modification dramat ically enhanced the original binding ability of native β-cyclodextrin by a fac tor 9. The binding constants of mono-6-p-nitrobenzoyl-β-cyclodextrin a nd other naphthalenes such as 1-methoxynaphthalene, 2-methoxynaphthalene, 1-N ,N-dimethylaminonaphthalene and 1-N,N-dimethylaminonaphthalene were obtained from the time-resolved fluorescence. The high binging ability of naphthalenes w ith NBCD make it is possible to assemble stable host-guest complexes.更多还原