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(s)-萘普生丙炔醇酯的合成
Synthesis of (s)-naproxen propionate
【摘要】 以(s)萘普生为原料,经二氯亚砜酰化为酰氯,与丙炔醇发生反应,合成萘普生丙炔醇酯,并用红外光谱、氢核磁共振谱对结构进行了表征。该方法反应条件温和,反应时间短,产率达82%。
【Abstract】 s ) Naproxen propionate was synthesized by reaction of propargyl alcohol with ( s ) (2 propinyl) 2 (6 methoxy 2 naphthyl) formyl chloride which was prepared from thionyl chloride and ( s ) naproxen in the presence of triethylamine,and the resulting compound was characterized by IR and 1HNMR .The reaction condition was mild and time was short,the yield was 82%.
- 【文献出处】 化学试剂 ,Chemical Reagents , 编辑部邮箱 ,2004年04期
- 【分类号】TQ463
- 【被引频次】2
- 【下载频次】255