【摘要】 目的　研究增殖细胞核抗原 （PCNA）、bcl₂蛋白在灰线牙龈组织和正常牙龈组织中的表达 ,探讨瓷熔附金属全冠修复的生物学效果。方法　采用免疫组化SP法 ,以瓷熔附金属全冠修复后建立出的家兔灰线牙龈实验动物模型为研究对象 ,检测PCNA、bcl₂蛋白在戴金属烤瓷全冠 3个月组、戴金属烤瓷全冠 6个月组和不戴金属烤瓷全冠组即对照组牙龈组织中的表达。结果　戴金属烤瓷全冠 3个月组与对照组PCNA有显著性差异 （P <0 0 5 ） ;戴金属烤瓷全冠 6个月组与对照组PCNA没有显著性差异 （P >0 0 5 ）。戴金属烤瓷全冠 3个月组、戴金属烤瓷全冠 6个月组与对照组bcl₂差异无显著性 （P >0 0 5 ）。结论　PCNA表达与灰线牙龈组织炎症反应有关 ;PCNA、bcl₂的表达 ,不表明灰线牙龈组织有异常增殖。更多还原

【Abstract】 Objective To study the expression of PCNA、bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals(PFM).Methods Gray gingival tissue animal model was established by PFM prosthesis and immunohistochemistry S-P method was used to detect the PCNA、bcl-2 protein expression in gingival tissue after 3 months, 6 months in PFM groups and control group.Results The expression of PCNA had significant difference between the 3th month group and the control group(P<0.05); no significant difference was found between the 6th month group and the control group(P>0.05). The expression of bcl-2 had no significant difference between the 6th month group and the control group(P>0.05).Conclusion There were a correlation between the expression of PCNA and inflammation of the gray gingival tissue;The expression of PCNA and bcl-2 protein does not indicate that gray gingival tissue had dysplasia change.更多还原