【摘要】 以氯苯和氯乙酰氯为反应原料,经傅列德尔-克拉夫茨酰基化反应一步合成2’,4-二氯苯乙酮。考察了物料配比,反应温度和溶剂对反应的影响,确定了以下较佳的反应条件:以二硫化碳作溶剂,反应温度15℃,以n(氯苯):n(氯乙酰氯):n(无水氯化铝)=1.0:1.2:1.8进料,反应4h左右,最终产物收率可以达到99.31％,纯度为99.00％。更多还原

【Abstract】 2’,4-dichloro-acetophenone was prepared via one-step reaction of Friedel-Crafts acyla tion, using chlorobenzene and chloroacetyl chloride as the material. The effects of the ratio of reagents, temperature and solvents on the reaction were investigated. The optimal reaction conditions were obtained as follows:n(chlorobenzene):n (chloroacetyl chloride):n(aluminium chloride anhydrous) = 1. 00 : 1. 20 : 1. 80 , carbon disulfide as solvent at 15 (C. After reaction for 4h, the yield and the purity of the product reached 99. 31% and 99. 00% respectively.更多还原