【摘要】 目的 :探讨人骨肉瘤组织中cyclinE和ki 6 7蛋白的表达。方法 :采用免疫组化S P法检测 30例骨肉瘤和10例骨软骨瘤组织中cyclinE和ki 6 7蛋白的表达情况。结果 :骨肉瘤组织中cyclinE及ki 6 7蛋白阳性表达率分别为 93.33%和 6 6 .6 7% ,骨软骨瘤中分别为 30 %和 10 % ,2者的阳性表达率在不同组织中差异有统计学意义 (P <0 .0 5 )。cyclinE蛋白表达强度与ki 6 7蛋白表达强度之间呈正相关 (rs=0 .6 4 1,P <0 .0 1)。结论 :骨肉瘤组织中cyclinE和ki 6 7蛋白均为高表达 ,它们与骨肉瘤的发生、发展有相关性。更多还原

【Abstract】 Aim: To evaluate the expression of cyclinE and ki-67 proteins in human osteosarcoma. Methods: S-P immunohistochemical method was used to detect expression of cyclinE and ki-67 proteins in 30 cases of osteosarcoma and 10 cases of osteochondroma. Results: The positive rate of cyclinE protein was 93.33% in osteosarcoma and 30% in osteochondroma,and there was significant difference between them(P<0.05). The positive rate of ki-67 protein was 66.67% in osteosarcoma and 10% in osteochondroma, and there was significant difference between them (P<0.01). There was positive correlation in staining intensity between cyclinE and ki-67 proteins in osteosarcoma(r s=0.641,P<0.05). Conclusion: The expressions of cyclinE and ki-67 are higher in osteosarcoma than those in osteochondroma.CyclinE and ki-67 proteins may play an important role in carcinogenesis and development of osteosarcoma.更多还原